I love that show, just make sure you bid it right. I used to drive semi with an ex so I know first hand a lot of hidden expenses in hauling loads from point A to point B. Here's a "Top 10 list"
1. Take into account for fuel usage and that fuel WILL cost more in another town.
2. Take into account wear and tear on equipment, breakdowns, tow bills, toll roads, food for the trip, tires, exc.
3. Make sure to look at deadlines and make sure it is possible without speeding, taking into account loading time, un-loading time, exc.
4. Make sure the load is within what your equipment can handle, as seen on the show sometimes people guess at the weight of an item and are WAY off.
5. Make sure you secure the load and re-check it every time you stop to make sure it hasn't shifted or straps need tightened or re-positioned.
6. Make sure your vehicle's tires are properly inflated and air filters are clean (Saves a boatload of fuel, a dollar saved is a dollar earned)
7. Be professional and polite when dealing with customers, good feedback is key to getting future customers to trust you.
8. Look out for idiots on the roadways. THEY ARE EVERYWHERE!
9. Make sure to get sleep and to eat, don't wear yourself out pushing too hard.
10. Make sure you have paperwork on your load and KNOW WHERE IT IS AT ALL TIMES.
Hope this helps and doesn't scare you off of it. It's a great way to travel and get to see some awesome sights and make money while doing it.